Dergi makalesi Açık Erişim
Ergun, Sercan; Arman, Kaifee; Temiz, Ebru; Bozgeyik, Ibrahim; Yumrutas, Onder; Safdar, Muhammad; Dagli, Hasan; Arslan, Ahmet; Oztuzcu, Serdar
{ "@context": "https://schema.org/", "@id": 63069, "@type": "ScholarlyArticle", "creator": [ { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Ergun, Sercan" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Arman, Kaifee" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Temiz, Ebru" }, { "@type": "Person", "affiliation": "Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey", "name": "Bozgeyik, Ibrahim" }, { "@type": "Person", "affiliation": "Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey", "name": "Yumrutas, Onder" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Safdar, Muhammad" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Dagli, Hasan" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Arslan, Ahmet" }, { "@type": "Person", "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", "name": "Oztuzcu, Serdar" } ], "datePublished": "2014-01-01", "description": "Caspases are important initiators and most well-known finishers of apoptosis. By changing the death propagation homeostatic equilibrium, their different expression patterns might trigger the progression of hazardous diseases like cancer. miR-221 is an oncogenic miRNA. It is known to have both anti-angiogenic and angiogenic effect. The aim of this work was to compare the expression levels of miR-221 and its target caspase-3 in different cancer cell lines and to find out a relationship between these two. We also tried to establish a prominent relationship between miR-221 and its role in apoptosis by studying their expression levels. Our results indicate that expression of caspase-3 is quite lower as compared to miR-221 expression in all of the selected cancer cell lines. As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3.", "headline": "Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines", "identifier": 63069, "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", "license": "http://www.opendefinition.org/licenses/cc-by", "name": "Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines", "url": "https://aperta.ulakbim.gov.tr/record/63069" }
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