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L-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in water

Aktas, Mehmet; Uyanik, Arzu; Eymur, Serkan; Yilmaz, Mustafa


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        "affiliation": "Selcuk Univ, Dept Chem, Konya, Turkey", 
        "name": "Aktas, Mehmet"
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      {
        "affiliation": "Selcuk Univ, Dept Chem, Konya, Turkey", 
        "name": "Uyanik, Arzu"
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      {
        "affiliation": "Giresun Univ, Dept Energy Syst Engn, Giresun, Turkey", 
        "name": "Eymur, Serkan"
      }, 
      {
        "affiliation": "Selcuk Univ, Dept Chem, Konya, Turkey", 
        "name": "Yilmaz, Mustafa"
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    "description": "A new series of water-compatible proline catalysts (4-6) derived from calixarene bearing a hydrophobic nature have been synthesised. It was found that the compound 4 was a highly efficient organocatalyst for aldol reactions occurred in the water. Under optimised reaction conditions, high yields (up to 82%), good enantioselectivities (ee up to 81%) and high diastereoselectivities (dr up to 91:9) were obtained.", 
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    "title": "L-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in water"
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