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L-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in water

Aktas, Mehmet; Uyanik, Arzu; Eymur, Serkan; Yilmaz, Mustafa


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/58845</identifier>
  <creators>
    <creator>
      <creatorName>Aktas, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Aktas</familyName>
      <affiliation>Selcuk Univ, Dept Chem, Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uyanik, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Uyanik</familyName>
      <affiliation>Selcuk Univ, Dept Chem, Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Eymur, Serkan</creatorName>
      <givenName>Serkan</givenName>
      <familyName>Eymur</familyName>
      <affiliation>Giresun Univ, Dept Energy Syst Engn, Giresun, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>Selcuk Univ, Dept Chem, Konya, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>L-Proline Derivatives Based On A Calix[4]Arene Scaffold As Chiral Organocatalysts For The Direct Asymmetric Aldol Reaction In Water</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/58845</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/10610278.2015.1073288</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A new series of water-compatible proline catalysts (4-6) derived from calixarene bearing a hydrophobic nature have been synthesised. It was found that the compound 4 was a highly efficient organocatalyst for aldol reactions occurred in the water. Under optimised reaction conditions, high yields (up to 82%), good enantioselectivities (ee up to 81%) and high diastereoselectivities (dr up to 91:9) were obtained.</description>
  </descriptions>
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