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gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

Dondas, H. Ali; Hempshall, Aiden; Narramore, Sarah; Kilner, Colin; Fishwick, Colin W. G.; Grigg, Ronald


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  "@context": "https://schema.org/", 
  "@id": 57931, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Dondas, H. Ali"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
      "name": "Hempshall, Aiden"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
      "name": "Narramore, Sarah"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
      "name": "Kilner, Colin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
      "name": "Fishwick, Colin W. G."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
      "name": "Grigg, Ronald"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.", 
  "headline": "gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades", 
  "identifier": 57931, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades", 
  "url": "https://aperta.ulakbim.gov.tr/record/57931"
}
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