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gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

Dondas, H. Ali; Hempshall, Aiden; Narramore, Sarah; Kilner, Colin; Fishwick, Colin W. G.; Grigg, Ronald


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{
  "DOI": "10.1016/j.tet.2016.01.025", 
  "abstract": "gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.", 
  "author": [
    {
      "family": "Dondas", 
      "given": " H. Ali"
    }, 
    {
      "family": "Hempshall", 
      "given": " Aiden"
    }, 
    {
      "family": "Narramore", 
      "given": " Sarah"
    }, 
    {
      "family": "Kilner", 
      "given": " Colin"
    }, 
    {
      "family": "Fishwick", 
      "given": " Colin W. G."
    }, 
    {
      "family": "Grigg", 
      "given": " Ronald"
    }
  ], 
  "container_title": "TETRAHEDRON", 
  "id": "57931", 
  "issue": "10", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1316-1329", 
  "title": "gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades", 
  "type": "article-journal", 
  "volume": "72"
}
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