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gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

Dondas, H. Ali; Hempshall, Aiden; Narramore, Sarah; Kilner, Colin; Fishwick, Colin W. G.; Grigg, Ronald


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/57931</identifier>
  <creators>
    <creator>
      <creatorName>Dondas, H. Ali</creatorName>
      <givenName>H. Ali</givenName>
      <familyName>Dondas</familyName>
    </creator>
    <creator>
      <creatorName>Hempshall, Aiden</creatorName>
      <givenName>Aiden</givenName>
      <familyName>Hempshall</familyName>
      <affiliation>Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Narramore, Sarah</creatorName>
      <givenName>Sarah</givenName>
      <familyName>Narramore</familyName>
      <affiliation>Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Kilner, Colin</creatorName>
      <givenName>Colin</givenName>
      <familyName>Kilner</familyName>
      <affiliation>Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Fishwick, Colin W. G.</creatorName>
      <givenName>Colin W. G.</givenName>
      <familyName>Fishwick</familyName>
      <affiliation>Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England</affiliation>
    </creator>
    <creator>
      <creatorName>Grigg, Ronald</creatorName>
      <givenName>Ronald</givenName>
      <familyName>Grigg</familyName>
      <affiliation>Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Gamma-Carboline Ac190 Analogues Via Palladium Catalysed Allene Insertion Stereo And Regioselective 3-And 5-Component Cascades</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/57931</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.tet.2016.01.025</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.</description>
  </descriptions>
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