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gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades

Dondas, H. Ali; Hempshall, Aiden; Narramore, Sarah; Kilner, Colin; Fishwick, Colin W. G.; Grigg, Ronald


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    "creators": [
      {
        "name": "Dondas, H. Ali"
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      {
        "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
        "name": "Hempshall, Aiden"
      }, 
      {
        "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
        "name": "Narramore, Sarah"
      }, 
      {
        "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
        "name": "Kilner, Colin"
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      {
        "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
        "name": "Fishwick, Colin W. G."
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      {
        "affiliation": "Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England", 
        "name": "Grigg, Ronald"
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    "description": "gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.", 
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      "issue": "10", 
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