1 Ocak 2016 Dergi makalesi Açık Erişim

Groeger, Nicole; Bock, Joerg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Katharina

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{
  "@context": "https://schema.org/", 
  "@id": 54537, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany", 
      "name": "Groeger, Nicole"
    }, 
    {
      "@type": "Person", 
      "name": "Bock, Joerg"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany", 
      "name": "Goehler, Daniela"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
      "name": "Blume, Nicole"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
      "name": "Lisson, Nicole"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
      "name": "Poeggel, Gerd"
    }, 
    {
      "@type": "Person", 
      "name": "Braun, Katharina"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "The present study in juvenile rats investigated a \"two-hit model\" to test the impact of prenatal stress exposure (\"first hit\") on the regulation of the synaptic plasticity immediate early genes Arc and Egr1 in response to a second neonatal stressor (\"second hit\") in a sex-specific manner. Three stress-exposed animal groups were compared at the age of 21 days in relation to unstressed controls (CON): preS animals were exposed to various unpredictable stressors during the last gestational trimester; postS animals were exposed to 45 min restraint stress at postnatal day 21, pre/postS animals were exposed to a combination of pre- and postnatal stress as described for the two previous groups. The postS and pre/postS groups were killed 2 h after exposure to the postnatal stressor, males and females were separately analyzed. In line with our hypothesis we detected sex-specific stress sensitivity for both analyzed proteins. Males did not show any significant changes in Arc expression irrespective of the stress condition. In contrast, females, which had been pre-exposed to prenatal stress, displayed an \"amplified\" Arc upregulation in response to postnatal stress (pre/postS group) compared to unstressed controls, which may reflect a \"sensitization\" effect of prenatal stress. For Egr1, the females did not show any stress-induced regulation irrespective of the stress condition, whereas in males, which were pre-exposed to prenatal stress, we observed a \"protective\" effect of prenatal stress on postnatal stress-induced downregulation of Egr1 expression (pre/postS group), which may indicate that prenatal stress exposure may induce \"resilience\".", 
  "headline": "Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner", 
  "identifier": 54537, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner", 
  "url": "https://aperta.ulakbim.gov.tr/record/54537"
}