1 Ocak 2016 Dergi makalesi Açık Erişim

Groeger, Nicole; Bock, Joerg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Katharina

JSON

{
  "conceptrecid": "54536", 
  "created": "2021-03-15T23:38:44.990341+00:00", 
  "doi": "10.1007/s00429-014-0889-3", 
  "files": [
    {
      "bucket": "20d210a1-2ed7-4628-b59e-d426acf09304", 
      "checksum": "md5:798384308088196ae6ebf45fc77a0cba", 
      "key": "bib-96bc282a-2824-43ac-a53a-252a1eac0bcf.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/20d210a1-2ed7-4628-b59e-d426acf09304/bib-96bc282a-2824-43ac-a53a-252a1eac0bcf.txt"
      }, 
      "size": 268, 
      "type": "txt"
    }
  ], 
  "id": 54537, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1007/s00429-014-0889-3.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/20d210a1-2ed7-4628-b59e-d426acf09304", 
    "doi": "https://doi.org/10.1007/s00429-014-0889-3", 
    "html": "https://aperta.ulakbim.gov.tr/record/54537", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/54537", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/54537"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany", 
        "name": "Groeger, Nicole"
      }, 
      {
        "name": "Bock, Joerg"
      }, 
      {
        "affiliation": "Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany", 
        "name": "Goehler, Daniela"
      }, 
      {
        "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
        "name": "Blume, Nicole"
      }, 
      {
        "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
        "name": "Lisson, Nicole"
      }, 
      {
        "affiliation": "Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany", 
        "name": "Poeggel, Gerd"
      }, 
      {
        "name": "Braun, Katharina"
      }
    ], 
    "description": "The present study in juvenile rats investigated a \"two-hit model\" to test the impact of prenatal stress exposure (\"first hit\") on the regulation of the synaptic plasticity immediate early genes Arc and Egr1 in response to a second neonatal stressor (\"second hit\") in a sex-specific manner. Three stress-exposed animal groups were compared at the age of 21 days in relation to unstressed controls (CON): preS animals were exposed to various unpredictable stressors during the last gestational trimester; postS animals were exposed to 45 min restraint stress at postnatal day 21, pre/postS animals were exposed to a combination of pre- and postnatal stress as described for the two previous groups. The postS and pre/postS groups were killed 2 h after exposure to the postnatal stressor, males and females were separately analyzed. In line with our hypothesis we detected sex-specific stress sensitivity for both analyzed proteins. Males did not show any significant changes in Arc expression irrespective of the stress condition. In contrast, females, which had been pre-exposed to prenatal stress, displayed an \"amplified\" Arc upregulation in response to postnatal stress (pre/postS group) compared to unstressed controls, which may reflect a \"sensitization\" effect of prenatal stress. For Egr1, the females did not show any stress-induced regulation irrespective of the stress condition, whereas in males, which were pre-exposed to prenatal stress, we observed a \"protective\" effect of prenatal stress on postnatal stress-induced downregulation of Egr1 expression (pre/postS group), which may indicate that prenatal stress exposure may induce \"resilience\".", 
    "doi": "10.1007/s00429-014-0889-3", 
    "has_grant": false, 
    "journal": {
      "issue": "1", 
      "pages": "679-685", 
      "title": "BRAIN STRUCTURE & FUNCTION", 
      "volume": "221"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2016-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "54537"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "54536"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 9.0, 
    "unique_downloads": 9.0, 
    "unique_views": 34.0, 
    "version_downloads": 9.0, 
    "version_unique_downloads": 9.0, 
    "version_unique_views": 34.0, 
    "version_views": 36.0, 
    "version_volume": 2412.0, 
    "views": 36.0, 
    "volume": 2412.0
  }, 
  "updated": "2021-03-15T23:38:45.037419+00:00"
}