1 Ocak 2016 Dergi makalesi Açık Erişim

Groeger, Nicole; Bock, Joerg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Katharina

Citation Style Language JSON

{
  "DOI": "10.1007/s00429-014-0889-3", 
  "abstract": "The present study in juvenile rats investigated a \"two-hit model\" to test the impact of prenatal stress exposure (\"first hit\") on the regulation of the synaptic plasticity immediate early genes Arc and Egr1 in response to a second neonatal stressor (\"second hit\") in a sex-specific manner. Three stress-exposed animal groups were compared at the age of 21 days in relation to unstressed controls (CON): preS animals were exposed to various unpredictable stressors during the last gestational trimester; postS animals were exposed to 45 min restraint stress at postnatal day 21, pre/postS animals were exposed to a combination of pre- and postnatal stress as described for the two previous groups. The postS and pre/postS groups were killed 2 h after exposure to the postnatal stressor, males and females were separately analyzed. In line with our hypothesis we detected sex-specific stress sensitivity for both analyzed proteins. Males did not show any significant changes in Arc expression irrespective of the stress condition. In contrast, females, which had been pre-exposed to prenatal stress, displayed an \"amplified\" Arc upregulation in response to postnatal stress (pre/postS group) compared to unstressed controls, which may reflect a \"sensitization\" effect of prenatal stress. For Egr1, the females did not show any stress-induced regulation irrespective of the stress condition, whereas in males, which were pre-exposed to prenatal stress, we observed a \"protective\" effect of prenatal stress on postnatal stress-induced downregulation of Egr1 expression (pre/postS group), which may indicate that prenatal stress exposure may induce \"resilience\".", 
  "author": [
    {
      "family": "Groeger", 
      "given": " Nicole"
    }, 
    {
      "family": "Bock", 
      "given": " Joerg"
    }, 
    {
      "family": "Goehler", 
      "given": " Daniela"
    }, 
    {
      "family": "Blume", 
      "given": " Nicole"
    }, 
    {
      "family": "Lisson", 
      "given": " Nicole"
    }, 
    {
      "family": "Poeggel", 
      "given": " Gerd"
    }, 
    {
      "family": "Braun", 
      "given": " Katharina"
    }
  ], 
  "container_title": "BRAIN STRUCTURE & FUNCTION", 
  "id": "54537", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "679-685", 
  "title": "Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner", 
  "type": "article-journal", 
  "volume": "221"
}