1 Ocak 2016 Dergi makalesi Açık Erişim

Groeger, Nicole; Bock, Joerg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Katharina

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/54537</identifier>
  <creators>
    <creator>
      <creatorName>Groeger, Nicole</creatorName>
      <givenName>Nicole</givenName>
      <familyName>Groeger</familyName>
      <affiliation>Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Bock, Joerg</creatorName>
      <givenName>Joerg</givenName>
      <familyName>Bock</familyName>
    </creator>
    <creator>
      <creatorName>Goehler, Daniela</creatorName>
      <givenName>Daniela</givenName>
      <familyName>Goehler</familyName>
      <affiliation>Univ Magdeburg, Dept Zool Dev Neurobiol, Inst Biol, Leipziger Str 44, D-39120 Magdeburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Blume, Nicole</creatorName>
      <givenName>Nicole</givenName>
      <familyName>Blume</familyName>
      <affiliation>Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Lisson, Nicole</creatorName>
      <givenName>Nicole</givenName>
      <familyName>Lisson</familyName>
      <affiliation>Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Poeggel, Gerd</creatorName>
      <givenName>Gerd</givenName>
      <familyName>Poeggel</familyName>
      <affiliation>Univ Leipzig, Inst Biol, Human Biol, Talstr 33, D-04103 Leipzig, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Braun, Katharina</creatorName>
      <givenName>Katharina</givenName>
      <familyName>Braun</familyName>
    </creator>
  </creators>
  <titles>
    <title>Stress In Utero Alters Neonatal Stress-Induced Regulation Of The Synaptic Plasticity Proteins Arc And Egr1 In A Sex-Specific Manner</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/54537</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00429-014-0889-3</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The present study in juvenile rats investigated a "two-hit model" to test the impact of prenatal stress exposure ("first hit") on the regulation of the synaptic plasticity immediate early genes Arc and Egr1 in response to a second neonatal stressor ("second hit") in a sex-specific manner. Three stress-exposed animal groups were compared at the age of 21 days in relation to unstressed controls (CON): preS animals were exposed to various unpredictable stressors during the last gestational trimester; postS animals were exposed to 45 min restraint stress at postnatal day 21, pre/postS animals were exposed to a combination of pre- and postnatal stress as described for the two previous groups. The postS and pre/postS groups were killed 2 h after exposure to the postnatal stressor, males and females were separately analyzed. In line with our hypothesis we detected sex-specific stress sensitivity for both analyzed proteins. Males did not show any significant changes in Arc expression irrespective of the stress condition. In contrast, females, which had been pre-exposed to prenatal stress, displayed an "amplified" Arc upregulation in response to postnatal stress (pre/postS group) compared to unstressed controls, which may reflect a "sensitization" effect of prenatal stress. For Egr1, the females did not show any stress-induced regulation irrespective of the stress condition, whereas in males, which were pre-exposed to prenatal stress, we observed a "protective" effect of prenatal stress on postnatal stress-induced downregulation of Egr1 expression (pre/postS group), which may indicate that prenatal stress exposure may induce "resilience".</description>
  </descriptions>
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