1 Ocak 2017 Dergi makalesi Açık Erişim

Alpugan, Serkan; Topkaya, Derya; Dumoulin, Fabienne

Dublin Core

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  <dc:creator>Alpugan, Serkan</dc:creator>
  <dc:creator>Topkaya, Derya</dc:creator>
  <dc:creator>Dumoulin, Fabienne</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>The tumor micro-environment is rich in glutathione. To exploit this feature for tumor-activatable porphyrin-based photosensitizers, a dimeric disulfide-bridged porphyrin has been designed and prepared, together with two reference derivatives, a non-cleavable dimer and a monomer. The three compounds have been investigated from a photochemical and photophysical point of view. It appears that the disulfide-bridged derivative exhibited intramolecular aggregation, but to an insufficient extent to induce a satisfying self-quenching of its photoproperties. Unlike expected, the non-cleavable dimer behaved like the monomeric derivative, due to the superior flexibility of the alkyl bridge over the disulfide bridge.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/52273</dc:identifier>
  <dc:identifier>oai:zenodo.org:52273</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF PORPHYRINS AND PHTHALOCYANINES 21(12) 918-924</dc:source>
  <dc:title>Disulfide-bridge dimeric porphyrin and their reference compounds for glutathione-based specific tumor-activation</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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