1 Ocak 2017 Dergi makalesi Açık Erişim

Alpugan, Serkan; Topkaya, Derya; Dumoulin, Fabienne

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  "@context": "https://schema.org/", 
  "@id": 52273, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey", 
      "name": "Alpugan, Serkan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey", 
      "name": "Topkaya, Derya"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey", 
      "name": "Dumoulin, Fabienne"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "The tumor micro-environment is rich in glutathione. To exploit this feature for tumor-activatable porphyrin-based photosensitizers, a dimeric disulfide-bridged porphyrin has been designed and prepared, together with two reference derivatives, a non-cleavable dimer and a monomer. The three compounds have been investigated from a photochemical and photophysical point of view. It appears that the disulfide-bridged derivative exhibited intramolecular aggregation, but to an insufficient extent to induce a satisfying self-quenching of its photoproperties. Unlike expected, the non-cleavable dimer behaved like the monomeric derivative, due to the superior flexibility of the alkyl bridge over the disulfide bridge.", 
  "headline": "Disulfide-bridge dimeric porphyrin and their reference compounds for glutathione-based specific tumor-activation", 
  "identifier": 52273, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Disulfide-bridge dimeric porphyrin and their reference compounds for glutathione-based specific tumor-activation", 
  "url": "https://aperta.ulakbim.gov.tr/record/52273"
}