1 Ocak 2017 Dergi makalesi Açık Erişim

Alpugan, Serkan; Topkaya, Derya; Dumoulin, Fabienne

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/52273</identifier>
  <creators>
    <creator>
      <creatorName>Alpugan, Serkan</creatorName>
      <givenName>Serkan</givenName>
      <familyName>Alpugan</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Topkaya, Derya</creatorName>
      <givenName>Derya</givenName>
      <familyName>Topkaya</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dumoulin, Fabienne</creatorName>
      <givenName>Fabienne</givenName>
      <familyName>Dumoulin</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Disulfide-Bridge Dimeric Porphyrin And Their Reference Compounds For Glutathione-Based Specific Tumor-Activation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/52273</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1142/S1088424617500961</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The tumor micro-environment is rich in glutathione. To exploit this feature for tumor-activatable porphyrin-based photosensitizers, a dimeric disulfide-bridged porphyrin has been designed and prepared, together with two reference derivatives, a non-cleavable dimer and a monomer. The three compounds have been investigated from a photochemical and photophysical point of view. It appears that the disulfide-bridged derivative exhibited intramolecular aggregation, but to an insufficient extent to induce a satisfying self-quenching of its photoproperties. Unlike expected, the non-cleavable dimer behaved like the monomeric derivative, due to the superior flexibility of the alkyl bridge over the disulfide bridge.</description>
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