1 Ocak 2017 Dergi makalesi Açık Erişim

Alpugan, Serkan; Topkaya, Derya; Dumoulin, Fabienne

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    "creators": [
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        "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey", 
        "name": "Alpugan, Serkan"
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      {
        "affiliation": "Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey", 
        "name": "Topkaya, Derya"
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      {
        "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey", 
        "name": "Dumoulin, Fabienne"
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    "description": "The tumor micro-environment is rich in glutathione. To exploit this feature for tumor-activatable porphyrin-based photosensitizers, a dimeric disulfide-bridged porphyrin has been designed and prepared, together with two reference derivatives, a non-cleavable dimer and a monomer. The three compounds have been investigated from a photochemical and photophysical point of view. It appears that the disulfide-bridged derivative exhibited intramolecular aggregation, but to an insufficient extent to induce a satisfying self-quenching of its photoproperties. Unlike expected, the non-cleavable dimer behaved like the monomeric derivative, due to the superior flexibility of the alkyl bridge over the disulfide bridge.", 
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    "journal": {
      "issue": "12", 
      "pages": "918-924", 
      "title": "JOURNAL OF PORPHYRINS AND PHTHALOCYANINES", 
      "volume": "21"
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    "title": "Disulfide-bridge dimeric porphyrin and their reference compounds for glutathione-based specific tumor-activation"
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