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Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

Algarawi, Maha; Erkol, Hakan; Luk, Alex; Ha, Seunghoon; Unlu, Mehmet B.; Gulsen, Gultekin; Nouizi, Farouk


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  <dc:creator>Algarawi, Maha</dc:creator>
  <dc:creator>Erkol, Hakan</dc:creator>
  <dc:creator>Luk, Alex</dc:creator>
  <dc:creator>Ha, Seunghoon</dc:creator>
  <dc:creator>Unlu, Mehmet B.</dc:creator>
  <dc:creator>Gulsen, Gultekin</dc:creator>
  <dc:creator>Nouizi, Farouk</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy-and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/5149</dc:identifier>
  <dc:identifier>oai:zenodo.org:5149</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOMEDICAL OPTICS EXPRESS 11(8) 4244-4254</dc:source>
  <dc:title>Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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