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Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

Algarawi, Maha; Erkol, Hakan; Luk, Alex; Ha, Seunghoon; Unlu, Mehmet B.; Gulsen, Gultekin; Nouizi, Farouk


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/5149</identifier>
  <creators>
    <creator>
      <creatorName>Algarawi, Maha</creatorName>
      <givenName>Maha</givenName>
      <familyName>Algarawi</familyName>
    </creator>
    <creator>
      <creatorName>Erkol, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Erkol</familyName>
      <affiliation>Bogazici Univ, Dept Phys, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Luk, Alex</creatorName>
      <givenName>Alex</givenName>
      <familyName>Luk</familyName>
      <affiliation>Univ Calif Irvine, Ctr Funct Oncoimaging, Irvine, CA 92697 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Ha, Seunghoon</creatorName>
      <givenName>Seunghoon</givenName>
      <familyName>Ha</familyName>
      <affiliation>Philips Healthcare, Pewaukee, WI 53002 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Unlu, Mehmet B.</creatorName>
      <givenName>Mehmet B.</givenName>
      <familyName>Unlu</familyName>
      <affiliation>Bogazici Univ, Dept Phys, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gulsen, Gultekin</creatorName>
      <givenName>Gultekin</givenName>
      <familyName>Gulsen</familyName>
    </creator>
    <creator>
      <creatorName>Nouizi, Farouk</creatorName>
      <givenName>Farouk</givenName>
      <familyName>Nouizi</familyName>
    </creator>
  </creators>
  <titles>
    <title>Resolving Tissue Chromophore Concentration At Mri Resolution Using Multi-Wavelength Photo-Magnetic Imaging</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/5149</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1364/BOE.397538</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy-and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement</description>
  </descriptions>
</resource>
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