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Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

Algarawi, Maha; Erkol, Hakan; Luk, Alex; Ha, Seunghoon; Unlu, Mehmet B.; Gulsen, Gultekin; Nouizi, Farouk


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{
  "@context": "https://schema.org/", 
  "@id": 5149, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Algarawi, Maha"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Phys, Istanbul, Turkey", 
      "name": "Erkol, Hakan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Calif Irvine, Ctr Funct Oncoimaging, Irvine, CA 92697 USA", 
      "name": "Luk, Alex"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Philips Healthcare, Pewaukee, WI 53002 USA", 
      "name": "Ha, Seunghoon"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Phys, Istanbul, Turkey", 
      "name": "Unlu, Mehmet B."
    }, 
    {
      "@type": "Person", 
      "name": "Gulsen, Gultekin"
    }, 
    {
      "@type": "Person", 
      "name": "Nouizi, Farouk"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy-and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement", 
  "headline": "Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging", 
  "identifier": 5149, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging", 
  "url": "https://aperta.ulakbim.gov.tr/record/5149"
}
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