1 Ocak 2017 Dergi makalesi Açık Erişim

Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.

Dublin Core

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  <dc:creator>Senturk, Berna</dc:creator>
  <dc:creator>Demircan, Burak M.</dc:creator>
  <dc:creator>Ozkan, Alper D.</dc:creator>
  <dc:creator>Tohumeken, Sehmus</dc:creator>
  <dc:creator>Delibasi, Tuncay</dc:creator>
  <dc:creator>Guler, Mustafa O.</dc:creator>
  <dc:creator>Tekinay, Ayse B.</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/50263</dc:identifier>
  <dc:identifier>oai:zenodo.org:50263</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOMATERIALS SCIENCE 5(7) 1293-1303</dc:source>
  <dc:title>Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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