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Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/50263</identifier> <creators> <creator> <creatorName>Senturk, Berna</creatorName> <givenName>Berna</givenName> <familyName>Senturk</familyName> <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Demircan, Burak M.</creatorName> <givenName>Burak M.</givenName> <familyName>Demircan</familyName> </creator> <creator> <creatorName>Ozkan, Alper D.</creatorName> <givenName>Alper D.</givenName> <familyName>Ozkan</familyName> <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Tohumeken, Sehmus</creatorName> <givenName>Sehmus</givenName> <familyName>Tohumeken</familyName> <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Delibasi, Tuncay</creatorName> <givenName>Tuncay</givenName> <familyName>Delibasi</familyName> </creator> <creator> <creatorName>Guler, Mustafa O.</creatorName> <givenName>Mustafa O.</givenName> <familyName>Guler</familyName> </creator> <creator> <creatorName>Tekinay, Ayse B.</creatorName> <givenName>Ayse B.</givenName> <familyName>Tekinay</familyName> </creator> </creators> <titles> <title>Diabetic Wound Regeneration Using Heparin-Mimetic Peptide Amphiphile Gel In Db/Db Mice</title> </titles> <publisher>Aperta</publisher> <publicationYear>2017</publicationYear> <dates> <date dateType="Issued">2017-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/50263</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c7bm00251c</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.</description> </descriptions> </resource>
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