1 Ocak 2017 Dergi makalesi Açık Erişim

Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/50263</identifier>
  <creators>
    <creator>
      <creatorName>Senturk, Berna</creatorName>
      <givenName>Berna</givenName>
      <familyName>Senturk</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demircan, Burak M.</creatorName>
      <givenName>Burak M.</givenName>
      <familyName>Demircan</familyName>
    </creator>
    <creator>
      <creatorName>Ozkan, Alper D.</creatorName>
      <givenName>Alper D.</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tohumeken, Sehmus</creatorName>
      <givenName>Sehmus</givenName>
      <familyName>Tohumeken</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Delibasi, Tuncay</creatorName>
      <givenName>Tuncay</givenName>
      <familyName>Delibasi</familyName>
    </creator>
    <creator>
      <creatorName>Guler, Mustafa O.</creatorName>
      <givenName>Mustafa O.</givenName>
      <familyName>Guler</familyName>
    </creator>
    <creator>
      <creatorName>Tekinay, Ayse B.</creatorName>
      <givenName>Ayse B.</givenName>
      <familyName>Tekinay</familyName>
    </creator>
  </creators>
  <titles>
    <title>Diabetic Wound Regeneration Using Heparin-Mimetic Peptide Amphiphile Gel In Db/Db Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/50263</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c7bm00251c</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.</description>
  </descriptions>
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