1 Ocak 2017 Dergi makalesi Açık Erişim

Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.

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{
  "@context": "https://schema.org/", 
  "@id": 50263, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Senturk, Berna"
    }, 
    {
      "@type": "Person", 
      "name": "Demircan, Burak M."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Ozkan, Alper D."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
      "name": "Tohumeken, Sehmus"
    }, 
    {
      "@type": "Person", 
      "name": "Delibasi, Tuncay"
    }, 
    {
      "@type": "Person", 
      "name": "Guler, Mustafa O."
    }, 
    {
      "@type": "Person", 
      "name": "Tekinay, Ayse B."
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.", 
  "headline": "Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice", 
  "identifier": 50263, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice", 
  "url": "https://aperta.ulakbim.gov.tr/record/50263"
}