1 Ocak 2017 Dergi makalesi Açık Erişim

Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.

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        "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Senturk, Berna"
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      {
        "name": "Demircan, Burak M."
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        "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Ozkan, Alper D."
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      {
        "affiliation": "Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Tohumeken, Sehmus"
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      {
        "name": "Delibasi, Tuncay"
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      {
        "name": "Guler, Mustafa O."
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    "description": "There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.", 
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      "issue": "7", 
      "pages": "1293-1303", 
      "title": "BIOMATERIALS SCIENCE", 
      "volume": "5"
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    "publication_date": "2017-01-01", 
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    "title": "Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice"
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