1 Ocak 2017 Dergi makalesi Açık Erişim

Senturk, Berna; Demircan, Burak M.; Ozkan, Alper D.; Tohumeken, Sehmus; Delibasi, Tuncay; Guler, Mustafa O.; Tekinay, Ayse B.

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{
  "DOI": "10.1039/c7bm00251c", 
  "abstract": "There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that the heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (alpha-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interfere with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.", 
  "author": [
    {
      "family": "Senturk", 
      "given": " Berna"
    }, 
    {
      "family": "Demircan", 
      "given": " Burak M."
    }, 
    {
      "family": "Ozkan", 
      "given": " Alper D."
    }, 
    {
      "family": "Tohumeken", 
      "given": " Sehmus"
    }, 
    {
      "family": "Delibasi", 
      "given": " Tuncay"
    }, 
    {
      "family": "Guler", 
      "given": " Mustafa O."
    }, 
    {
      "family": "Tekinay", 
      "given": " Ayse B."
    }
  ], 
  "container_title": "BIOMATERIALS SCIENCE", 
  "id": "50263", 
  "issue": "7", 
  "issued": {
    "date-parts": [
      [
        2017, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1293-1303", 
  "title": "Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice", 
  "type": "article-journal", 
  "volume": "5"
}