1 Ocak 2017 Dergi makalesi Açık Erişim

Sahin, A.; Spiroux, F.; Guedon, I.; Arslan, F. B.; Sarcan, E. T.; Ozkan, T.; Colak, N.; Yuksel, S.; Ozdemir, S.; Ozdemir, B.; Akbas, S.; Ultav, G.; Aktas, Y.; Capan, Y.

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Spiroux, F.</subfield>
    <subfield code="u">Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Guedon, I.</subfield>
    <subfield code="u">Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Arslan, F. B.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sarcan, E. T.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozkan, T.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Colak, N.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Yuksel, S.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozdemir, S.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozdemir, B.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Akbas, S.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ultav, G.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Aktas, Y.</subfield>
    <subfield code="u">Erciyes Univ, Fac Pharm, Dept Pharmaceut Technol, TR-38070 Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Capan, Y.</subfield>
    <subfield code="u">Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">PHARMAZIE</subfield>
    <subfield code="v">72</subfield>
    <subfield code="n">9</subfield>
    <subfield code="c">525-528</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1691/ph.2017.7015</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Sahin, A.</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:47803</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2017-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/47803/files/bib-5128784e-8644-40fb-8ca1-ad17346f94a9.txt</subfield>
    <subfield code="z">md5:3ecc68d4fced1ecc933eb56c1eeaff55</subfield>
    <subfield code="s">357</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20210315220737.0</controlfield>
  <controlfield tag="001">47803</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly( lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA TPGS (d-alpha-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier. It was found that encapsulation efficiencies of NPs varied between 17.9 and 41.9 % and the highest encapsulation efficiency was obtained with 0.5% PVA + 0.1% TPGS (coded as PLGA PVA/TPGS NPs). PLGA PVA/TPGS NPs were characterized and compared with PLGA PVA NPs, which was obtained by 0.5% PVA alone. Polydispersity index of PLGA PVA/TPGS and PLGA PVA NPs were found to be 0.08 and 0.15, respectively. Incorporation of TPGS with PVA slightly decreased the initial ibuprofen release. Transmission electron microscopy analyses demonstrated a nearly uniform particle size distribution and spherical particle shape of the PLGA PVA/TPGS NPs. Additionally, PLGA PVA/TPGS NPs were significantly more cytotoxic than PLGA PVA NPs on the MCF-7 (human breast adenocarcinoma cells) and Caco-2 (human epithelial colorectal adenocarcinoma) cells (p&amp;lt;0.05). Also PLGA PVA/TPGS NPs were not cytotoxic on normal cells (L929, mouse healthy fibroblast cells) (p&amp;gt;0.05). In conclusion, these results indicated that using a combination of TPGS and PVA as an emulsifier in nanoprecipitation could be a promising approach for preparing ibuprofen loaded PLGA NPs because of their improved characteristics and anticancer activity.</subfield>
  </datafield>
</record>