1 Ocak 2017 Dergi makalesi Açık Erişim

Sahin, A.; Spiroux, F.; Guedon, I.; Arslan, F. B.; Sarcan, E. T.; Ozkan, T.; Colak, N.; Yuksel, S.; Ozdemir, S.; Ozdemir, B.; Akbas, S.; Ultav, G.; Aktas, Y.; Capan, Y.

Dublin Core

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Sahin, A.</dc:creator>
  <dc:creator>Spiroux, F.</dc:creator>
  <dc:creator>Guedon, I.</dc:creator>
  <dc:creator>Arslan, F. B.</dc:creator>
  <dc:creator>Sarcan, E. T.</dc:creator>
  <dc:creator>Ozkan, T.</dc:creator>
  <dc:creator>Colak, N.</dc:creator>
  <dc:creator>Yuksel, S.</dc:creator>
  <dc:creator>Ozdemir, S.</dc:creator>
  <dc:creator>Ozdemir, B.</dc:creator>
  <dc:creator>Akbas, S.</dc:creator>
  <dc:creator>Ultav, G.</dc:creator>
  <dc:creator>Aktas, Y.</dc:creator>
  <dc:creator>Capan, Y.</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly( lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA TPGS (d-alpha-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier. It was found that encapsulation efficiencies of NPs varied between 17.9 and 41.9 % and the highest encapsulation efficiency was obtained with 0.5% PVA + 0.1% TPGS (coded as PLGA PVA/TPGS NPs). PLGA PVA/TPGS NPs were characterized and compared with PLGA PVA NPs, which was obtained by 0.5% PVA alone. Polydispersity index of PLGA PVA/TPGS and PLGA PVA NPs were found to be 0.08 and 0.15, respectively. Incorporation of TPGS with PVA slightly decreased the initial ibuprofen release. Transmission electron microscopy analyses demonstrated a nearly uniform particle size distribution and spherical particle shape of the PLGA PVA/TPGS NPs. Additionally, PLGA PVA/TPGS NPs were significantly more cytotoxic than PLGA PVA NPs on the MCF-7 (human breast adenocarcinoma cells) and Caco-2 (human epithelial colorectal adenocarcinoma) cells (p&lt;0.05). Also PLGA PVA/TPGS NPs were not cytotoxic on normal cells (L929, mouse healthy fibroblast cells) (p&gt;0.05). In conclusion, these results indicated that using a combination of TPGS and PVA as an emulsifier in nanoprecipitation could be a promising approach for preparing ibuprofen loaded PLGA NPs because of their improved characteristics and anticancer activity.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/47803</dc:identifier>
  <dc:identifier>oai:zenodo.org:47803</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>PHARMAZIE 72(9) 525-528</dc:source>
  <dc:title>Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>