1 Ocak 2017 Dergi makalesi Açık Erişim

Sahin, A.; Spiroux, F.; Guedon, I.; Arslan, F. B.; Sarcan, E. T.; Ozkan, T.; Colak, N.; Yuksel, S.; Ozdemir, S.; Ozdemir, B.; Akbas, S.; Ultav, G.; Aktas, Y.; Capan, Y.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/47803</identifier>
  <creators>
    <creator>
      <creatorName>Sahin, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Sahin</familyName>
    </creator>
    <creator>
      <creatorName>Spiroux, F.</creatorName>
      <givenName>F.</givenName>
      <familyName>Spiroux</familyName>
      <affiliation>Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France</affiliation>
    </creator>
    <creator>
      <creatorName>Guedon, I.</creatorName>
      <givenName>I.</givenName>
      <familyName>Guedon</familyName>
      <affiliation>Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France</affiliation>
    </creator>
    <creator>
      <creatorName>Arslan, F. B.</creatorName>
      <givenName>F. B.</givenName>
      <familyName>Arslan</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sarcan, E. T.</creatorName>
      <givenName>E. T.</givenName>
      <familyName>Sarcan</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkan, T.</creatorName>
      <givenName>T.</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Colak, N.</creatorName>
      <givenName>N.</givenName>
      <familyName>Colak</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yuksel, S.</creatorName>
      <givenName>S.</givenName>
      <familyName>Yuksel</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdemir, S.</creatorName>
      <givenName>S.</givenName>
      <familyName>Ozdemir</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdemir, B.</creatorName>
      <givenName>B.</givenName>
      <familyName>Ozdemir</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akbas, S.</creatorName>
      <givenName>S.</givenName>
      <familyName>Akbas</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ultav, G.</creatorName>
      <givenName>G.</givenName>
      <familyName>Ultav</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aktas, Y.</creatorName>
      <givenName>Y.</givenName>
      <familyName>Aktas</familyName>
      <affiliation>Erciyes Univ, Fac Pharm, Dept Pharmaceut Technol, TR-38070 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Capan, Y.</creatorName>
      <givenName>Y.</givenName>
      <familyName>Capan</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Using Pva And Tpgs As Combined Emulsifier In Nanoprecipitation Method Improves Characteristics And Anticancer Activity Of Ibuprofen Loaded Plga Nanoparticles</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/47803</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1691/ph.2017.7015</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly( lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA TPGS (d-alpha-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier. It was found that encapsulation efficiencies of NPs varied between 17.9 and 41.9 % and the highest encapsulation efficiency was obtained with 0.5% PVA + 0.1% TPGS (coded as PLGA PVA/TPGS NPs). PLGA PVA/TPGS NPs were characterized and compared with PLGA PVA NPs, which was obtained by 0.5% PVA alone. Polydispersity index of PLGA PVA/TPGS and PLGA PVA NPs were found to be 0.08 and 0.15, respectively. Incorporation of TPGS with PVA slightly decreased the initial ibuprofen release. Transmission electron microscopy analyses demonstrated a nearly uniform particle size distribution and spherical particle shape of the PLGA PVA/TPGS NPs. Additionally, PLGA PVA/TPGS NPs were significantly more cytotoxic than PLGA PVA NPs on the MCF-7 (human breast adenocarcinoma cells) and Caco-2 (human epithelial colorectal adenocarcinoma) cells (p&amp;lt;0.05). Also PLGA PVA/TPGS NPs were not cytotoxic on normal cells (L929, mouse healthy fibroblast cells) (p&amp;gt;0.05). In conclusion, these results indicated that using a combination of TPGS and PVA as an emulsifier in nanoprecipitation could be a promising approach for preparing ibuprofen loaded PLGA NPs because of their improved characteristics and anticancer activity.</description>
  </descriptions>
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