1 Ocak 2017 Dergi makalesi Açık Erişim

Sahin, A.; Spiroux, F.; Guedon, I.; Arslan, F. B.; Sarcan, E. T.; Ozkan, T.; Colak, N.; Yuksel, S.; Ozdemir, S.; Ozdemir, B.; Akbas, S.; Ultav, G.; Aktas, Y.; Capan, Y.

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  "doi": "10.1691/ph.2017.7015", 
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    "creators": [
      {
        "name": "Sahin, A."
      }, 
      {
        "affiliation": "Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France", 
        "name": "Spiroux, F."
      }, 
      {
        "affiliation": "Univ Angers, Fac Pharm, Dept Pharmaceut Technol, Angers, France", 
        "name": "Guedon, I."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Arslan, F. B."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Sarcan, E. T."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Ozkan, T."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Colak, N."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Yuksel, S."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Ozdemir, S."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Ozdemir, B."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Akbas, S."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Ultav, G."
      }, 
      {
        "affiliation": "Erciyes Univ, Fac Pharm, Dept Pharmaceut Technol, TR-38070 Kayseri, Turkey", 
        "name": "Aktas, Y."
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey", 
        "name": "Capan, Y."
      }
    ], 
    "description": "In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly( lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA TPGS (d-alpha-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier. It was found that encapsulation efficiencies of NPs varied between 17.9 and 41.9 % and the highest encapsulation efficiency was obtained with 0.5% PVA + 0.1% TPGS (coded as PLGA PVA/TPGS NPs). PLGA PVA/TPGS NPs were characterized and compared with PLGA PVA NPs, which was obtained by 0.5% PVA alone. Polydispersity index of PLGA PVA/TPGS and PLGA PVA NPs were found to be 0.08 and 0.15, respectively. Incorporation of TPGS with PVA slightly decreased the initial ibuprofen release. Transmission electron microscopy analyses demonstrated a nearly uniform particle size distribution and spherical particle shape of the PLGA PVA/TPGS NPs. Additionally, PLGA PVA/TPGS NPs were significantly more cytotoxic than PLGA PVA NPs on the MCF-7 (human breast adenocarcinoma cells) and Caco-2 (human epithelial colorectal adenocarcinoma) cells (p<0.05). Also PLGA PVA/TPGS NPs were not cytotoxic on normal cells (L929, mouse healthy fibroblast cells) (p>0.05). In conclusion, these results indicated that using a combination of TPGS and PVA as an emulsifier in nanoprecipitation could be a promising approach for preparing ibuprofen loaded PLGA NPs because of their improved characteristics and anticancer activity.", 
    "doi": "10.1691/ph.2017.7015", 
    "has_grant": false, 
    "journal": {
      "issue": "9", 
      "pages": "525-528", 
      "title": "PHARMAZIE", 
      "volume": "72"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2017-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles"
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