1 Ocak 2017 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, M.; Durmus, H.; Aysal, F.; Guelsen-Parman, Y.; Oflazer, P.; Deymeer, F.; Saruhan-Direskeneli, G.

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Alahgholi-Hajibehzad, M.</dc:creator>
  <dc:creator>Durmus, H.</dc:creator>
  <dc:creator>Aysal, F.</dc:creator>
  <dc:creator>Guelsen-Parman, Y.</dc:creator>
  <dc:creator>Oflazer, P.</dc:creator>
  <dc:creator>Deymeer, F.</dc:creator>
  <dc:creator>Saruhan-Direskeneli, G.</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>Impairment of the suppressive function of regulatory T (T-reg) cells has been reported in myasthenia gravis (MG). In this study, cytokine-related mechanisms that may lead to the defect of T-reg were investigated in patients with anti-acetylcholine receptor antibody-positive MG (AChR+MG). Proliferation and cytokine production of responder T (T-resp) cells in response to polyclonal activation were measured in a suppression assay. The effect of interleukin (IL)-21 on suppression was evaluated in vitro in co-culture. IL-21 increased the proliferation of T-resp cells in T-resp/T-reg co-cultures. T-resp cells from patients with MG secreted significantly lower levels of IL-2. In patients with MG, IL-2 levels did not change with the addition of T-reg to cultures, whereas it decreased significantly in controls. In T-resp/T-reg co-cultures, IL-4, IL-6 and IL-10 production increased in the presence of T-reg in patients. Interferon (IFN)-gamma was decreased, whereas IL-17A was increased in both patient and control groups. IL-21 inhibited the secretion of IL-4 in MG and healthy controls (HC), and IL-17A in HC only. The results demonstrated that IL-21 enhances the proliferation of T-resp cells in the presence of T-reg. An effect of IL-21 mainly on T-resp cells through IL-2 is implicated.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/47199</dc:identifier>
  <dc:identifier>oai:zenodo.org:47199</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>CLINICAL AND EXPERIMENTAL IMMUNOLOGY 190(2) 201-207</dc:source>
  <dc:title>The effect of interleukin (IL)-21 and CD4(+)CD25(++) T cells on cytokine production of CD4(+) responder T cells in patients with myasthenia gravis</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>