1 Ocak 2017 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, M.; Durmus, H.; Aysal, F.; Guelsen-Parman, Y.; Oflazer, P.; Deymeer, F.; Saruhan-Direskeneli, G.

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        "name": "Alahgholi-Hajibehzad, M."
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      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Durmus, H."
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      {
        "affiliation": "Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey", 
        "name": "Aysal, F."
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Guelsen-Parman, Y."
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Oflazer, P."
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
        "name": "Deymeer, F."
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey", 
        "name": "Saruhan-Direskeneli, G."
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    "description": "Impairment of the suppressive function of regulatory T (T-reg) cells has been reported in myasthenia gravis (MG). In this study, cytokine-related mechanisms that may lead to the defect of T-reg were investigated in patients with anti-acetylcholine receptor antibody-positive MG (AChR+MG). Proliferation and cytokine production of responder T (T-resp) cells in response to polyclonal activation were measured in a suppression assay. The effect of interleukin (IL)-21 on suppression was evaluated in vitro in co-culture. IL-21 increased the proliferation of T-resp cells in T-resp/T-reg co-cultures. T-resp cells from patients with MG secreted significantly lower levels of IL-2. In patients with MG, IL-2 levels did not change with the addition of T-reg to cultures, whereas it decreased significantly in controls. In T-resp/T-reg co-cultures, IL-4, IL-6 and IL-10 production increased in the presence of T-reg in patients. Interferon (IFN)-gamma was decreased, whereas IL-17A was increased in both patient and control groups. IL-21 inhibited the secretion of IL-4 in MG and healthy controls (HC), and IL-17A in HC only. The results demonstrated that IL-21 enhances the proliferation of T-resp cells in the presence of T-reg. An effect of IL-21 mainly on T-resp cells through IL-2 is implicated.", 
    "doi": "10.1111/cei.13006", 
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    "journal": {
      "issue": "2", 
      "pages": "201-207", 
      "title": "CLINICAL AND EXPERIMENTAL IMMUNOLOGY", 
      "volume": "190"
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    "license": {
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    "publication_date": "2017-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "The effect of interleukin (IL)-21 and CD4(+)CD25(++) T cells on cytokine production of CD4(+) responder T cells in patients with myasthenia gravis"
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