1 Ocak 2017 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, M.; Durmus, H.; Aysal, F.; Guelsen-Parman, Y.; Oflazer, P.; Deymeer, F.; Saruhan-Direskeneli, G.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/47199</identifier>
  <creators>
    <creator>
      <creatorName>Alahgholi-Hajibehzad, M.</creatorName>
      <givenName>M.</givenName>
      <familyName>Alahgholi-Hajibehzad</familyName>
    </creator>
    <creator>
      <creatorName>Durmus, H.</creatorName>
      <givenName>H.</givenName>
      <familyName>Durmus</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aysal, F.</creatorName>
      <givenName>F.</givenName>
      <familyName>Aysal</familyName>
      <affiliation>Bakirkoy Res &amp; Training Hosp Psychiat &amp; Neurol Di, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guelsen-Parman, Y.</creatorName>
      <givenName>Y.</givenName>
      <familyName>Guelsen-Parman</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oflazer, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Oflazer</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Deymeer, F.</creatorName>
      <givenName>F.</givenName>
      <familyName>Deymeer</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Saruhan-Direskeneli, G.</creatorName>
      <givenName>G.</givenName>
      <familyName>Saruhan-Direskeneli</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Effect Of Interleukin (Il)-21 And Cd4(+)Cd25(++) T Cells On Cytokine Production Of Cd4(+) Responder T Cells In Patients With Myasthenia Gravis</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/47199</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1111/cei.13006</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Impairment of the suppressive function of regulatory T (T-reg) cells has been reported in myasthenia gravis (MG). In this study, cytokine-related mechanisms that may lead to the defect of T-reg were investigated in patients with anti-acetylcholine receptor antibody-positive MG (AChR+MG). Proliferation and cytokine production of responder T (T-resp) cells in response to polyclonal activation were measured in a suppression assay. The effect of interleukin (IL)-21 on suppression was evaluated in vitro in co-culture. IL-21 increased the proliferation of T-resp cells in T-resp/T-reg co-cultures. T-resp cells from patients with MG secreted significantly lower levels of IL-2. In patients with MG, IL-2 levels did not change with the addition of T-reg to cultures, whereas it decreased significantly in controls. In T-resp/T-reg co-cultures, IL-4, IL-6 and IL-10 production increased in the presence of T-reg in patients. Interferon (IFN)-gamma was decreased, whereas IL-17A was increased in both patient and control groups. IL-21 inhibited the secretion of IL-4 in MG and healthy controls (HC), and IL-17A in HC only. The results demonstrated that IL-21 enhances the proliferation of T-resp cells in the presence of T-reg. An effect of IL-21 mainly on T-resp cells through IL-2 is implicated.</description>
  </descriptions>
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