1 Ocak 2017 Dergi makalesi Açık Erişim

Alahgholi-Hajibehzad, M.; Durmus, H.; Aysal, F.; Guelsen-Parman, Y.; Oflazer, P.; Deymeer, F.; Saruhan-Direskeneli, G.

JSON-LD (schema.org)

{
  "@context": "https://schema.org/", 
  "@id": 47199, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Alahgholi-Hajibehzad, M."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Durmus, H."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey", 
      "name": "Aysal, F."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Guelsen-Parman, Y."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Oflazer, P."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey", 
      "name": "Deymeer, F."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey", 
      "name": "Saruhan-Direskeneli, G."
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Impairment of the suppressive function of regulatory T (T-reg) cells has been reported in myasthenia gravis (MG). In this study, cytokine-related mechanisms that may lead to the defect of T-reg were investigated in patients with anti-acetylcholine receptor antibody-positive MG (AChR+MG). Proliferation and cytokine production of responder T (T-resp) cells in response to polyclonal activation were measured in a suppression assay. The effect of interleukin (IL)-21 on suppression was evaluated in vitro in co-culture. IL-21 increased the proliferation of T-resp cells in T-resp/T-reg co-cultures. T-resp cells from patients with MG secreted significantly lower levels of IL-2. In patients with MG, IL-2 levels did not change with the addition of T-reg to cultures, whereas it decreased significantly in controls. In T-resp/T-reg co-cultures, IL-4, IL-6 and IL-10 production increased in the presence of T-reg in patients. Interferon (IFN)-gamma was decreased, whereas IL-17A was increased in both patient and control groups. IL-21 inhibited the secretion of IL-4 in MG and healthy controls (HC), and IL-17A in HC only. The results demonstrated that IL-21 enhances the proliferation of T-resp cells in the presence of T-reg. An effect of IL-21 mainly on T-resp cells through IL-2 is implicated.", 
  "headline": "The effect of interleukin (IL)-21 and CD4(+)CD25(++) T cells on cytokine production of CD4(+) responder T cells in patients with myasthenia gravis", 
  "identifier": 47199, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The effect of interleukin (IL)-21 and CD4(+)CD25(++) T cells on cytokine production of CD4(+) responder T cells in patients with myasthenia gravis", 
  "url": "https://aperta.ulakbim.gov.tr/record/47199"
}