1 Ocak 2017 Dergi makalesi Açık Erişim

Yildiz, Zehra Irem; Celebioglu, Asli; Uyar, Tamer

Dublin Core

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Yildiz, Zehra Irem</dc:creator>
  <dc:creator>Celebioglu, Asli</dc:creator>
  <dc:creator>Uyar, Tamer</dc:creator>
  <dc:date>2017-01-01</dc:date>
  <dc:description>In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD, Captisol (R)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-beta-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-beta-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 +/- 290 nm for sulfisoxazole/SBE7-beta-CD-IC NF and 890 +/- 415 nm for pure SBE7-beta-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-beta-CD in sulfisoxazole/SBE7-beta-CD-IC NF sample was confirmed by H-1 NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-beta-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/43991</dc:identifier>
  <dc:identifier>oai:zenodo.org:43991</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>INTERNATIONAL JOURNAL OF PHARMACEUTICS 531(2) 550-558</dc:source>
  <dc:title>Polymer-free electrospun nanofibers from sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>