1 Ocak 2017 Dergi makalesi Açık Erişim

Yildiz, Zehra Irem; Celebioglu, Asli; Uyar, Tamer

JSON

{
  "conceptrecid": "43990", 
  "created": "2021-03-15T21:15:27.532797+00:00", 
  "doi": "10.1016/j.ijpharm.2017.04.047", 
  "files": [
    {
      "bucket": "8ba2d37c-ffaa-465d-9ffe-ba5c189d26dc", 
      "checksum": "md5:ebb9076635acbb5b766d8fcf4c0596ce", 
      "key": "bib-e850c70e-29b8-43be-8e25-57d9fbb197df.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/8ba2d37c-ffaa-465d-9ffe-ba5c189d26dc/bib-e850c70e-29b8-43be-8e25-57d9fbb197df.txt"
      }, 
      "size": 298, 
      "type": "txt"
    }
  ], 
  "id": 43991, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.ijpharm.2017.04.047.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/8ba2d37c-ffaa-465d-9ffe-ba5c189d26dc", 
    "doi": "https://doi.org/10.1016/j.ijpharm.2017.04.047", 
    "html": "https://aperta.ulakbim.gov.tr/record/43991", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/43991", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/43991"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
        "name": "Yildiz, Zehra Irem"
      }, 
      {
        "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
        "name": "Celebioglu, Asli"
      }, 
      {
        "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
        "name": "Uyar, Tamer"
      }
    ], 
    "description": "In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD, Captisol (R)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-beta-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-beta-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 +/- 290 nm for sulfisoxazole/SBE7-beta-CD-IC NF and 890 +/- 415 nm for pure SBE7-beta-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-beta-CD in sulfisoxazole/SBE7-beta-CD-IC NF sample was confirmed by H-1 NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-beta-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.", 
    "doi": "10.1016/j.ijpharm.2017.04.047", 
    "has_grant": false, 
    "journal": {
      "issue": "2", 
      "pages": "550-558", 
      "title": "INTERNATIONAL JOURNAL OF PHARMACEUTICS", 
      "volume": "531"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2017-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "43991"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "43990"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Polymer-free electrospun nanofibers from sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 10.0, 
    "unique_downloads": 10.0, 
    "unique_views": 64.0, 
    "version_downloads": 10.0, 
    "version_unique_downloads": 10.0, 
    "version_unique_views": 64.0, 
    "version_views": 68.0, 
    "version_volume": 2980.0, 
    "views": 68.0, 
    "volume": 2980.0
  }, 
  "updated": "2021-03-15T21:15:27.584020+00:00"
}