1 Ocak 2017 Dergi makalesi Açık Erişim

Yildiz, Zehra Irem; Celebioglu, Asli; Uyar, Tamer

Citation Style Language JSON

{
  "DOI": "10.1016/j.ijpharm.2017.04.047", 
  "abstract": "In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD, Captisol (R)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-beta-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-beta-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 +/- 290 nm for sulfisoxazole/SBE7-beta-CD-IC NF and 890 +/- 415 nm for pure SBE7-beta-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-beta-CD in sulfisoxazole/SBE7-beta-CD-IC NF sample was confirmed by H-1 NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-beta-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.", 
  "author": [
    {
      "family": "Yildiz", 
      "given": " Zehra Irem"
    }, 
    {
      "family": "Celebioglu", 
      "given": " Asli"
    }, 
    {
      "family": "Uyar", 
      "given": " Tamer"
    }
  ], 
  "container_title": "INTERNATIONAL JOURNAL OF PHARMACEUTICS", 
  "id": "43991", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2017, 
        1, 
        1
      ]
    ]
  }, 
  "page": "550-558", 
  "title": "Polymer-free electrospun nanofibers from sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole", 
  "type": "article-journal", 
  "volume": "531"
}