1 Ocak 2017 Dergi makalesi Açık Erişim

Yildiz, Zehra Irem; Celebioglu, Asli; Uyar, Tamer

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/43991</identifier>
  <creators>
    <creator>
      <creatorName>Yildiz, Zehra Irem</creatorName>
      <givenName>Zehra Irem</givenName>
      <familyName>Yildiz</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Celebioglu, Asli</creatorName>
      <givenName>Asli</givenName>
      <familyName>Celebioglu</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uyar, Tamer</creatorName>
      <givenName>Tamer</givenName>
      <familyName>Uyar</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Polymer-Free Electrospun Nanofibers From Sulfobutyl Ether(7)-Beta-Cyclodextrin (Sbe7-Beta-Cd) Inclusion Complex With Sulfisoxazole: Fast-Dissolving And Enhanced Water-Solubility Of Sulfisoxazole</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/43991</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ijpharm.2017.04.047</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD, Captisol (R)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-beta-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-beta-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 +/- 290 nm for sulfisoxazole/SBE7-beta-CD-IC NF and 890 +/- 415 nm for pure SBE7-beta-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-beta-CD in sulfisoxazole/SBE7-beta-CD-IC NF sample was confirmed by H-1 NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-beta-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.</description>
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