1 Ocak 2017 Dergi makalesi Açık Erişim

Yildiz, Zehra Irem; Celebioglu, Asli; Uyar, Tamer

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{
  "@context": "https://schema.org/", 
  "@id": 43991, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Yildiz, Zehra Irem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Celebioglu, Asli"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey", 
      "name": "Uyar, Tamer"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD, Captisol (R)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-beta-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-beta-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 +/- 290 nm for sulfisoxazole/SBE7-beta-CD-IC NF and 890 +/- 415 nm for pure SBE7-beta-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-beta-CD in sulfisoxazole/SBE7-beta-CD-IC NF sample was confirmed by H-1 NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-beta-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.", 
  "headline": "Polymer-free electrospun nanofibers from sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole", 
  "identifier": 43991, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Polymer-free electrospun nanofibers from sulfobutyl ether(7)-beta-cyclodextrin (SBE7-beta-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole", 
  "url": "https://aperta.ulakbim.gov.tr/record/43991"
}