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Production of (S)-(-)-1-(1'-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Kurbanoglu, Esabi B.; Zilbeyaz, Kani; Kurbanoglu, Namudar I.; Taskin, Mesut; Kilic, Hamdullah


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        "affiliation": "Ataturk Univ, Fac Arts & Sci, Dept Biol, TR-25240 Erzurum, Turkey", 
        "name": "Kurbanoglu, Esabi B."
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      {
        "affiliation": "Ataturk Univ, Fac Arts & Sci, Dept Chem, TR-25240 Erzurum, Turkey", 
        "name": "Zilbeyaz, Kani"
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      {
        "affiliation": "Sakarya Univ, Hendek Fac Educ, Dept Chem, TR-54300 Sakarya, Turkey", 
        "name": "Kurbanoglu, Namudar I."
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      {
        "affiliation": "Ataturk Univ, Fac Arts & Sci, Dept Biol, TR-25240 Erzurum, Turkey", 
        "name": "Taskin, Mesut"
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      {
        "affiliation": "Ataturk Univ, Fac Arts & Sci, Dept Chem, TR-25240 Erzurum, Turkey", 
        "name": "Kilic, Hamdullah"
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    "description": "The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1'-naphthyl) ethanol ( 2), an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 degrees C, and pH 6.5. The production of 2 with excellent enantiomeric excess (> 99%), and good conversion (100%) and yield (78%) under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess (ee) of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.", 
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      "pages": "685-692", 
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