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Production of (S)-(-)-1-(1'-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Kurbanoglu, Esabi B.; Zilbeyaz, Kani; Kurbanoglu, Namudar I.; Taskin, Mesut; Kilic, Hamdullah


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{
  "URL": "https://aperta.ulakbim.gov.tr/record/39797", 
  "abstract": "The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1'-naphthyl) ethanol ( 2), an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 degrees C, and pH 6.5. The production of 2 with excellent enantiomeric excess (> 99%), and good conversion (100%) and yield (78%) under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess (ee) of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.", 
  "author": [
    {
      "family": "Kurbanoglu", 
      "given": " Esabi B."
    }, 
    {
      "family": "Zilbeyaz", 
      "given": " Kani"
    }, 
    {
      "family": "Kurbanoglu", 
      "given": " Namudar I."
    }, 
    {
      "family": "Taskin", 
      "given": " Mesut"
    }, 
    {
      "family": "Kilic", 
      "given": " Hamdullah"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF CHEMISTRY", 
  "id": "39797", 
  "issue": "6", 
  "issued": {
    "date-parts": [
      [
        2008, 
        1, 
        1
      ]
    ]
  }, 
  "page": "685-692", 
  "title": "Production of (S)-(-)-1-(1'-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone", 
  "type": "article-journal", 
  "volume": "32"
}
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