1 Ocak 2018 Dergi makalesi Açık Erişim

Armutcu, Canan; Uzun, Lokman; Denizli, Adil

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/33061</identifier>
  <creators>
    <creator>
      <creatorName>Armutcu, Canan</creatorName>
      <givenName>Canan</givenName>
      <familyName>Armutcu</familyName>
      <affiliation>Hacettepe Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uzun, Lokman</creatorName>
      <givenName>Lokman</givenName>
      <familyName>Uzun</familyName>
      <affiliation>Hacettepe Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Denizli, Adil</creatorName>
      <givenName>Adil</givenName>
      <familyName>Denizli</familyName>
      <affiliation>Hacettepe Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Determination Of Ochratoxin A Traces In Foodstuffs: Comparison Of An Automated On-Line Two-Dimensional High-Performance Liquid Chromatography And Off-Line Immunoaffinity-High-Performance Liquid Chromatography System</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/33061</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.chroma.2018.07.057</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Automated on-line two-dimensional high-performance liquid chromatography method (2D-HPLC) is proposed to determine Ochratoxin A (OTA) in food samples as an alternative to OTA immunoaffinity column (IAC). An on-line 2D-HPLC system is designed for the analysis of OTA using an affinity-based monolithic column in the first dimension and reversed-phase C18 column in the second dimension. Initially, optimal OTA separation efficiency is determined through traditional HPLC system consisting of a P(HEMAPA) monolithic column coupled with HPLC system. Secondly, after providing optimum conditions, OTA determination was investigated through the 2D-HPLC system. According to results, 2D-HPLC system showed good linearity in the range 0.5 to 20 ng/mL with limit of detection (LOD) and limit of quantification (LOQ) values of 21.2 pg/mL and 64.3 pg/mL, respectively. The P(HEMAPA)-4 monolithic column displayed good recovery of OTA ranging from 104.34% to 107.33%. Relative standard deviations (RSD) varied in the range 0.21% to 1.31% thus indicating the efficiency of P(HEMAPA)-4 monolithic column developed for OTA. (C) 2018 Elsevier B.V. All rights reserved.</description>
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