1 Ocak 2010 Dergi makalesi Açık Erişim

Eyigor, Ozhan; Minbay, Zehra; Cavusoglu, Ilkin

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  <dc:creator>Eyigor, Ozhan</dc:creator>
  <dc:creator>Minbay, Zehra</dc:creator>
  <dc:creator>Cavusoglu, Ilkin</dc:creator>
  <dc:date>2010-01-01</dc:date>
  <dc:description>Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/28437</dc:identifier>
  <dc:identifier>oai:zenodo.org:28437</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ENDOCRINE 37(1) 167-172</dc:source>
  <dc:title>Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>