1 Ocak 2010 Dergi makalesi Açık Erişim

Eyigor, Ozhan; Minbay, Zehra; Cavusoglu, Ilkin

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{
  "@context": "https://schema.org/", 
  "@id": 28437, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
      "name": "Eyigor, Ozhan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
      "name": "Minbay, Zehra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
      "name": "Cavusoglu, Ilkin"
    }
  ], 
  "datePublished": "2010-01-01", 
  "description": "Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.", 
  "headline": "Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry", 
  "identifier": 28437, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry", 
  "url": "https://aperta.ulakbim.gov.tr/record/28437"
}