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Eyigor, Ozhan; Minbay, Zehra; Cavusoglu, Ilkin
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/28437</identifier> <creators> <creator> <creatorName>Eyigor, Ozhan</creatorName> <givenName>Ozhan</givenName> <familyName>Eyigor</familyName> <affiliation>Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation> </creator> <creator> <creatorName>Minbay, Zehra</creatorName> <givenName>Zehra</givenName> <familyName>Minbay</familyName> <affiliation>Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation> </creator> <creator> <creatorName>Cavusoglu, Ilkin</creatorName> <givenName>Ilkin</givenName> <familyName>Cavusoglu</familyName> <affiliation>Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation> </creator> </creators> <titles> <title>Activation Of Orexin Neurons Through Non-Nmda Glutamate Receptors Evidenced By C-Fos Immunohistochemistry</title> </titles> <publisher>Aperta</publisher> <publicationYear>2010</publicationYear> <dates> <date dateType="Issued">2010-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/28437</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s12020-009-9284-x</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.</description> </descriptions> </resource>
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