1 Ocak 2010 Dergi makalesi Açık Erişim

Eyigor, Ozhan; Minbay, Zehra; Cavusoglu, Ilkin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/28437</identifier>
  <creators>
    <creator>
      <creatorName>Eyigor, Ozhan</creatorName>
      <givenName>Ozhan</givenName>
      <familyName>Eyigor</familyName>
      <affiliation>Uludag Univ, Dept Histol &amp; Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Minbay, Zehra</creatorName>
      <givenName>Zehra</givenName>
      <familyName>Minbay</familyName>
      <affiliation>Uludag Univ, Dept Histol &amp; Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cavusoglu, Ilkin</creatorName>
      <givenName>Ilkin</givenName>
      <familyName>Cavusoglu</familyName>
      <affiliation>Uludag Univ, Dept Histol &amp; Embryol, Fac Med, TR-16059 Bursa, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Activation Of Orexin Neurons Through Non-Nmda Glutamate Receptors Evidenced By C-Fos Immunohistochemistry</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2010</publicationYear>
  <dates>
    <date dateType="Issued">2010-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/28437</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s12020-009-9284-x</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.</description>
  </descriptions>
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