1 Ocak 2010 Dergi makalesi Açık Erişim

Eyigor, Ozhan; Minbay, Zehra; Cavusoglu, Ilkin

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        "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
        "name": "Eyigor, Ozhan"
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      {
        "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
        "name": "Minbay, Zehra"
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      {
        "affiliation": "Uludag Univ, Dept Histol & Embryol, Fac Med, TR-16059 Bursa, Turkey", 
        "name": "Cavusoglu, Ilkin"
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    "description": "Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.", 
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      "issue": "1", 
      "pages": "167-172", 
      "title": "ENDOCRINE", 
      "volume": "37"
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    "publication_date": "2010-01-01", 
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    "title": "Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry"
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