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Chemoenzymatic Conversion of Linoleic Acid into Conjugated Linoleic Acid

Demir, Ayhan S.; Talpur, Farah N.


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{
  "DOI": "10.1021/jf903521b", 
  "abstract": "An efficient chemoenzymatic method for preparing conjugated linoleic acid (CLA) using free linoleic acid (LA) as a substrate is described. In the first step, LA was transformed into 10-hydroxy-cis-12-octadecenoic acid (HA) by the whole cells of Lactobacillus plantarum after 48 h of incubation. The preincubation of whole cells with 0.03% LA resulted in a better yield of HA (480 mg/g) compared to cells grown without LA. In a second fast microwave step, HA was converted to cis-9, trans-11-octadecadienoic acid in the presence of iodine as a catalyst over a silica gel surface. The advantage of this method in preparing cis-9,trans-11 CLA is simple via the whole cell bioconversion of LA into HA via L. plantarum followed by the fast microwave-assisted synthesis of cis-9,trans-11 CLA in higher yields.", 
  "author": [
    {
      "family": "Demir", 
      "given": " Ayhan S."
    }, 
    {
      "family": "Talpur", 
      "given": " Farah N."
    }
  ], 
  "container_title": "JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY", 
  "id": "28173", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2010, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1646-1652", 
  "title": "Chemoenzymatic Conversion of Linoleic Acid into Conjugated Linoleic Acid", 
  "type": "article-journal", 
  "volume": "58"
}
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