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Genome-wide Association Studies for Milk Production Traits and Persistency of First Calving Holstein Cattle in Türkiye

Erdoğan, Metin; Çinkaya, Samet; Brenig, Bertram; Çelikeloğlu, Koray; Demirtaş, Mustafa; Sarıibrahimoğlu, Suat; Tekerli, Mustafa


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    <subfield code="a">&lt;p&gt;The study presents a comprehensive investigation into the genetic determinants&lt;br&gt;
of 100-day milk yield (100DMY), 305-day milk yield (305DMY), total milk yield&lt;br&gt;
(TMY), and persistency using first lactation records of 374 Holstein heifers reared&lt;br&gt;
in a private farm at &amp;Ccedil;anakkale province of T&amp;uuml;rkiye, employing a genome-wide&lt;br&gt;
association study (GWAS) approach. The research underscores the substantial&lt;br&gt;
genetic component underlying these economically important traits through&lt;br&gt;
detailed descriptive statistics and heritability estimations. The estimated&lt;br&gt;
moderate to high heritabilities (0.32&amp;ndash;0.54) for milk production traits suggest the&lt;br&gt;
feasibility of targeted genetic improvement strategies. By leveraging GWAS, the&lt;br&gt;
study identifies many significant and suggestively significant single nucleotide&lt;br&gt;
polymorphisms (SNP) associated with studied traits. Noteworthy genes have&lt;br&gt;
identified in this analysis include BCAS3, MALRD1, CTNND2, DOCK1, TMEM132C,&lt;br&gt;
NRP1, CNTNAP2, GPRIN2, PLEKHA5, GLRA1, SCN7A, HHEX, KTM2C, RAB40C,&lt;br&gt;
RAB11FIP3, and FXYD6. These findings provide valuable understandings of&lt;br&gt;
the genetic background of milk production and persistency in Holstein cattle,&lt;br&gt;
shedding light on specific genomic regions and candidate genes playing pivotal&lt;br&gt;
roles in these traits. This research contributes valuable knowledge to the field&lt;br&gt;
of dairy cattle genetics and informs future breeding efforts to improve milk&lt;br&gt;
production sustainability and efficiency in Holstein cattle populations.&lt;/p&gt;</subfield>
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