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Genome-wide Association Studies for Milk Production Traits and Persistency of First Calving Holstein Cattle in Türkiye

Erdoğan, Metin; Çinkaya, Samet; Brenig, Bertram; Çelikeloğlu, Koray; Demirtaş, Mustafa; Sarıibrahimoğlu, Suat; Tekerli, Mustafa


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/274008</identifier>
  <creators>
    <creator>
      <creatorName>Erdoğan, Metin</creatorName>
      <givenName>Metin</givenName>
      <familyName>Erdoğan</familyName>
      <affiliation>Afyon Kocatepe Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Çinkaya, Samet</creatorName>
      <givenName>Samet</givenName>
      <familyName>Çinkaya</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0736-4571</nameIdentifier>
      <affiliation>Afyon Kocatepe Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Brenig, Bertram</creatorName>
      <givenName>Bertram</givenName>
      <familyName>Brenig</familyName>
      <affiliation>Institute of Veterinary Medicine, Georg August University Göttingen, Göttingen, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Çelikeloğlu, Koray</creatorName>
      <givenName>Koray</givenName>
      <familyName>Çelikeloğlu</familyName>
      <affiliation>Afyon Kocatepe Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Demirtaş, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Demirtaş</familyName>
      <affiliation>Afyon Kocatepe Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Sarıibrahimoğlu, Suat</creatorName>
      <givenName>Suat</givenName>
      <familyName>Sarıibrahimoğlu</familyName>
      <affiliation>Kaanlar Agriculture and Livestock Farm</affiliation>
    </creator>
    <creator>
      <creatorName>Tekerli, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Tekerli</familyName>
      <affiliation>Afyon Kocatepe Üniversitesi</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Genome-Wide Association Studies For Milk Production Traits And Persistency Of First Calving Holstein Cattle In Türkiye</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2024</publicationYear>
  <subjects>
    <subject>gwas</subject>
    <subject>candidate genes</subject>
    <subject>milk production</subject>
    <subject>persistency</subject>
    <subject>Holstein heifers</subject>
    <subject>cattle</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2024-09-02</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Dataset"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/274008</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3389/fvets.2024.1461075</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The study presents a comprehensive investigation into the genetic determinants&lt;br&gt;
of 100-day milk yield (100DMY), 305-day milk yield (305DMY), total milk yield&lt;br&gt;
(TMY), and persistency using first lactation records of 374 Holstein heifers reared&lt;br&gt;
in a private farm at &amp;Ccedil;anakkale province of T&amp;uuml;rkiye, employing a genome-wide&lt;br&gt;
association study (GWAS) approach. The research underscores the substantial&lt;br&gt;
genetic component underlying these economically important traits through&lt;br&gt;
detailed descriptive statistics and heritability estimations. The estimated&lt;br&gt;
moderate to high heritabilities (0.32&amp;ndash;0.54) for milk production traits suggest the&lt;br&gt;
feasibility of targeted genetic improvement strategies. By leveraging GWAS, the&lt;br&gt;
study identifies many significant and suggestively significant single nucleotide&lt;br&gt;
polymorphisms (SNP) associated with studied traits. Noteworthy genes have&lt;br&gt;
identified in this analysis include BCAS3, MALRD1, CTNND2, DOCK1, TMEM132C,&lt;br&gt;
NRP1, CNTNAP2, GPRIN2, PLEKHA5, GLRA1, SCN7A, HHEX, KTM2C, RAB40C,&lt;br&gt;
RAB11FIP3, and FXYD6. These findings provide valuable understandings of&lt;br&gt;
the genetic background of milk production and persistency in Holstein cattle,&lt;br&gt;
shedding light on specific genomic regions and candidate genes playing pivotal&lt;br&gt;
roles in these traits. This research contributes valuable knowledge to the field&lt;br&gt;
of dairy cattle genetics and informs future breeding efforts to improve milk&lt;br&gt;
production sustainability and efficiency in Holstein cattle populations.&lt;/p&gt;</description>
  </descriptions>
</resource>
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