1 Ocak 2022 Dergi makalesi Açık Erişim

Erken, O.; Romano, F.; Grotberg, J. B.; Muradoglu, M.

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{
  "@context": "https://schema.org/", 
  "@id": 258557, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey", 
      "name": "Erken, O."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Lille, Arts & Metiers Inst Technol, Lab Mecan Fluides Lille Kampe de Feriet, CNRS,ONERA,Cent Lille,UMR 9014,LMFL, F-59000 Lille, France", 
      "name": "Romano, F."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA", 
      "name": "Grotberg, J. B."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey", 
      "name": "Muradoglu, M."
    }
  ], 
  "datePublished": "2022-01-01", 
  "description": "Capillary instability of a two-layer liquid film lining a rigid tube is studied computationally as a model for liquid plug formation and closure of human airways. The two-layer liquid consists of a serous layer, also called the periciliary liquid layer, at the inner side and a mucus layer at the outer side. Together, they form the airway surface liquid lining the airway wall and surrounding an air core. Liquid plug formation occurs due to Plateau-Rayleigh instability when the liquid film thickness exceeds a critical value. Numerical simulations are performed for the entire closure process, including the pre- and post-coalescence phases. The mechanical stresses and their gradients on the airway wall are investigated for physiologically relevant ranges of the mucus-to-serous thickness ratio, the viscosity ratio, and the air-mucus and serous-mucus surface tensions encompassing healthy and pathological conditions of a typical adult human lung. The growth rate of the two-layer model is found to be higher in comparison with a one-layer equivalent configuration. This leads to a much sooner closure in the two-layer model than that in the corresponding one-layer model. Moreover, it is found that the serous layer generally provides an effective protection to the pulmonary epithelium against high shear stress excursions and their gradients. A linear stability analysis is also performed, and the results are found to be in good qualitative agreement with the simulations. Finally, a secondary coalescence that may occur during the post-closure phase is investigated.", 
  "headline": "Capillary instability of a two-layer annular film: an airway closure model", 
  "identifier": 258557, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Capillary instability of a two-layer annular film: an airway closure model", 
  "url": "https://aperta.ulakbim.gov.tr/record/258557"
}