1 Ocak 2022 Dergi makalesi Açık Erişim

Erken, O.; Romano, F.; Grotberg, J. B.; Muradoglu, M.

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        "affiliation": "Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey", 
        "name": "Erken, O."
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      {
        "affiliation": "Univ Lille, Arts & Metiers Inst Technol, Lab Mecan Fluides Lille Kampe de Feriet, CNRS,ONERA,Cent Lille,UMR 9014,LMFL, F-59000 Lille, France", 
        "name": "Romano, F."
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      {
        "affiliation": "Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA", 
        "name": "Grotberg, J. B."
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      {
        "affiliation": "Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey", 
        "name": "Muradoglu, M."
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    "description": "Capillary instability of a two-layer liquid film lining a rigid tube is studied computationally as a model for liquid plug formation and closure of human airways. The two-layer liquid consists of a serous layer, also called the periciliary liquid layer, at the inner side and a mucus layer at the outer side. Together, they form the airway surface liquid lining the airway wall and surrounding an air core. Liquid plug formation occurs due to Plateau-Rayleigh instability when the liquid film thickness exceeds a critical value. Numerical simulations are performed for the entire closure process, including the pre- and post-coalescence phases. The mechanical stresses and their gradients on the airway wall are investigated for physiologically relevant ranges of the mucus-to-serous thickness ratio, the viscosity ratio, and the air-mucus and serous-mucus surface tensions encompassing healthy and pathological conditions of a typical adult human lung. The growth rate of the two-layer model is found to be higher in comparison with a one-layer equivalent configuration. This leads to a much sooner closure in the two-layer model than that in the corresponding one-layer model. Moreover, it is found that the serous layer generally provides an effective protection to the pulmonary epithelium against high shear stress excursions and their gradients. A linear stability analysis is also performed, and the results are found to be in good qualitative agreement with the simulations. Finally, a secondary coalescence that may occur during the post-closure phase is investigated.", 
    "doi": "10.1017/jfm.2021.1126", 
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    "journal": {
      "title": "JOURNAL OF FLUID MECHANICS", 
      "volume": "934"
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    "publication_date": "2022-01-01", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
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    "title": "Capillary instability of a two-layer annular film: an airway closure model"
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