1 Ocak 2022 Dergi makalesi Açık Erişim

Erken, O.; Romano, F.; Grotberg, J. B.; Muradoglu, M.

Citation Style Language JSON

{
  "DOI": "10.1017/jfm.2021.1126", 
  "abstract": "Capillary instability of a two-layer liquid film lining a rigid tube is studied computationally as a model for liquid plug formation and closure of human airways. The two-layer liquid consists of a serous layer, also called the periciliary liquid layer, at the inner side and a mucus layer at the outer side. Together, they form the airway surface liquid lining the airway wall and surrounding an air core. Liquid plug formation occurs due to Plateau-Rayleigh instability when the liquid film thickness exceeds a critical value. Numerical simulations are performed for the entire closure process, including the pre- and post-coalescence phases. The mechanical stresses and their gradients on the airway wall are investigated for physiologically relevant ranges of the mucus-to-serous thickness ratio, the viscosity ratio, and the air-mucus and serous-mucus surface tensions encompassing healthy and pathological conditions of a typical adult human lung. The growth rate of the two-layer model is found to be higher in comparison with a one-layer equivalent configuration. This leads to a much sooner closure in the two-layer model than that in the corresponding one-layer model. Moreover, it is found that the serous layer generally provides an effective protection to the pulmonary epithelium against high shear stress excursions and their gradients. A linear stability analysis is also performed, and the results are found to be in good qualitative agreement with the simulations. Finally, a secondary coalescence that may occur during the post-closure phase is investigated.", 
  "author": [
    {
      "family": "Erken", 
      "given": " O."
    }, 
    {
      "family": "Romano", 
      "given": " F."
    }, 
    {
      "family": "Grotberg", 
      "given": " J. B."
    }, 
    {
      "family": "Muradoglu", 
      "given": " M."
    }
  ], 
  "container_title": "JOURNAL OF FLUID MECHANICS", 
  "id": "258557", 
  "issued": {
    "date-parts": [
      [
        2022, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Capillary instability of a two-layer annular film: an airway closure model", 
  "type": "article-journal", 
  "volume": "934"
}