1 Ocak 2022 Dergi makalesi Açık Erişim

Erken, O.; Romano, F.; Grotberg, J. B.; Muradoglu, M.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/258557</identifier>
  <creators>
    <creator>
      <creatorName>Erken, O.</creatorName>
      <givenName>O.</givenName>
      <familyName>Erken</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Romano, F.</creatorName>
      <givenName>F.</givenName>
      <familyName>Romano</familyName>
      <affiliation>Univ Lille, Arts &amp; Metiers Inst Technol, Lab Mecan Fluides Lille Kampe de Feriet, CNRS,ONERA,Cent Lille,UMR 9014,LMFL, F-59000 Lille, France</affiliation>
    </creator>
    <creator>
      <creatorName>Grotberg, J. B.</creatorName>
      <givenName>J. B.</givenName>
      <familyName>Grotberg</familyName>
      <affiliation>Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Muradoglu, M.</creatorName>
      <givenName>M.</givenName>
      <familyName>Muradoglu</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey</affiliation>
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  </creators>
  <titles>
    <title>Capillary Instability Of A Two-Layer Annular Film: An Airway Closure Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/258557</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1017/jfm.2021.1126</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
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  <descriptions>
    <description descriptionType="Abstract">Capillary instability of a two-layer liquid film lining a rigid tube is studied computationally as a model for liquid plug formation and closure of human airways. The two-layer liquid consists of a serous layer, also called the periciliary liquid layer, at the inner side and a mucus layer at the outer side. Together, they form the airway surface liquid lining the airway wall and surrounding an air core. Liquid plug formation occurs due to Plateau-Rayleigh instability when the liquid film thickness exceeds a critical value. Numerical simulations are performed for the entire closure process, including the pre- and post-coalescence phases. The mechanical stresses and their gradients on the airway wall are investigated for physiologically relevant ranges of the mucus-to-serous thickness ratio, the viscosity ratio, and the air-mucus and serous-mucus surface tensions encompassing healthy and pathological conditions of a typical adult human lung. The growth rate of the two-layer model is found to be higher in comparison with a one-layer equivalent configuration. This leads to a much sooner closure in the two-layer model than that in the corresponding one-layer model. Moreover, it is found that the serous layer generally provides an effective protection to the pulmonary epithelium against high shear stress excursions and their gradients. A linear stability analysis is also performed, and the results are found to be in good qualitative agreement with the simulations. Finally, a secondary coalescence that may occur during the post-closure phase is investigated.</description>
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